Abstract
Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC 50 values were assessed between 0.3 and 3 μM. Compound 32 ( K i = 0.4 μM) is the most potent TR inhibitor described so far.
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