New signaling routes for an old drug: lipoxin A4 might mediate heme oxygenase-1 induction by aspirin. Focus on “Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells”

Abstract

over the past decade, heme oxygenase-1 (HO-1) has emerged as an important mediator of antioxidant and anti-inflammatory actions. HO-1 antisense and knockout studies as well as clinical investigations have clearly shown that HO-1 assumes a central role in cellular antioxidant defenses, and,