Abstract
Abstract A rapid first derivative spectrophotometric assay of bretylium tosylate, hyoscine butylbromide, oxyphenonium bromide, cetrimide and benzalkonium chloride in pure and in pharmaceutical formulation is developed, The assay depends upon extracting the picrate salt of these quaternised compounds into chloroform from aqueous medium and measurement of peak amplitude at 430 nm or peak - trough amplitude at 365/330 nm. Linear correlation over the concentration range of 5–20 ug ml−1 of the investigated compounds is obtained. The recovery percentage of the pure compound varied from 99.5 to 100.6%. The developed method is simple, sensitive, accurate and suitable for routine analysis of these quaternised compounds in bulk powder and in pharmaceutical formulations.
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