New self-assembled layers composed with gold nanoparticles, cysteamine and dihydrolipoic acid deposited on bare gold template for highly sensitive and selective simultaneous sensing of dopamine in the presence of interfering ascorbic and uric acids

Teresa Łuczak,Małgorzata Osińska

doi:10.1007/s10008-016-3416-z

Abstract

A gold bare template modified with self-assembled layers (SAMs) composed of gold nanoparticles and organic S-containing compound: cysteamine and dihydrolipoic acid were prepared. The electrode with SAMs endowed with gold nanoparticles gave a high catalytic effect for dopamine electrooxidation alone and in the presence of biogenic interfering compounds: ascorbic acid and uric acid in solution at pH 7. For this novel sensor, a linear relationship between the current response of dopamine at the potential of peak maximum (jp) and the concentration of this compound in solution (cDA) was found over the range 0.1 μM to 0.85 mM with the detection limit of 0.023 μM.Graphical abstractᅟ

Highlights

Dopamine (DA) belongs to catecholamine neurotransmittersa biologically important group of compounds which are mediators in transmitting messages between neurons [1, 2]
In the study presented here, the voltammetric performance of gold modified with dihydrolipoic acid (DHLA), cysteamine (CA) and the gold nanoparticle (Au-NPs) layers was studied for electrochemical sensing of dopamine alone and in the presence of ascorbic acid and uric acid in aqueous solution, pH 7
Having analysed the results of our study reported in the present paper and in our previous projects as well as other results reported in literature and related to the modification of gold electrodes for dopamine sensing, we have concluded that the dopamine detection level depends to a high extent on the molecular structure that linked the surface of gold with gold nanoparticles

Summary

Introduction

Dopamine (DA) belongs to catecholamine neurotransmittersa biologically important group of compounds which are mediators in transmitting messages between neurons [1, 2]. In the study presented here, the voltammetric performance of gold modified with dihydrolipoic acid (DHLA), cysteamine (CA) and the gold nanoparticle (Au-NPs) layers was studied for electrochemical sensing of dopamine alone and in the presence of ascorbic acid and uric acid in aqueous solution, pH 7.

Results

Conclusion