Abstract
Seven new compounds, namely talaromanloid A (1), talaromydene (2), 10-hydroxy-8-demethyltalaromydine and 11-hydroxy-8-demethyltalaromydine (3 and 4), talaromylectone (5), and ditalaromylectones A and B (6 and 7), together with seven known compounds were identified from a marine-derived fungus, Talaromyces mangshanicus BTBU20211089, which was isolated from a sediment sample collected from the South China Sea. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D, and 2D NMR techniques. The absolute configurations of 1 and 2 were elucidated by comparing experimental and calculated ECD spectra. Compounds 1, 2, 6, and 7 are new compounds possessing a novel carbon skeleton. Compound 6 is a dimeric molecule of 3 and 9. Compound 7 shared a unique structure of the cyclized dimer of 3 and 4. All the compounds were tested for their bioactivities against Staphylococcus aureus, Escherichia coli, and Candida albicans.
Highlights
Drugs 2022, 20, 79. https://doi.org/Marine-derived fungi represent the most prolific source of new chemical entries with diverse bioactivities [1,2]
During our ongoing investigations into bioactive natural products from marinederived microorganisms [10,11,12,13], a fungal strain of Talaromyces mangshanicus BTBU20211089, which was isolated from a sediment sample collected from the South China Sea, was found to be active against Candida albicans
Chemical investigation of this fungus cultured in rice solid media led to the isolation and identification of seven new compounds, namely, talaromanloid A (1), talaromydene (2), 10-hydroxy-8-demethyltalaromydine and
Summary
Marine-derived fungi represent the most prolific source of new chemical entries with diverse bioactivities [1,2]. During our ongoing investigations into bioactive natural products from marinederived microorganisms [10,11,12,13], a fungal strain of Talaromyces mangshanicus BTBU20211089, which was isolated from a sediment sample collected from the South China Sea, was found to be active against Candida albicans. Chemical investigation of this fungus cultured in rice solid media led to the isolation and identification of seven new compounds, namely, talaromanloid A (1), talaromydene (2), 10-hydroxy-8-demethyltalaromydine and. We report the isolation, structure elucidation, and bioactivities of these compounds
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