Abstract
In Canada, cardiovirus isolates related to Saffold virus were detected in nasopharyngeal aspirates from 3 children with respiratory symptoms. Polyprotein sequence of the Can112051-06 isolate had 91.2% aa identity with Saffold virus; however, EF and CD loops of the viral surface varied substantially.
Highlights
In Canada, cardiovirus isolates related to Saffold virus were detected in nasopharyngeal aspirates from 3 children with respiratory symptoms
Our findings suggest a pathogenic role for SAF-V-like viruses in humans
The polyprotein sequences of the Can112051-06 strain and the original US strain were related, the EF and CD loop structures varied substantially (61.8% and 67.5% aa identities, respectively)
Summary
In Canada, cardiovirus isolates related to Saffold virus were detected in nasopharyngeal aspirates from 3 children with respiratory symptoms. A new cardiovirus provisionally named Saffold virus (SAF-V) was isolated from a stool sample of an 8-month-old girl with fever [10]. Saffold Cardioviruses in Children, Canada human respiratory syncytial virus, and human metapneumovirus) [11] as well as RT-PCR assays for enteroviruses and parechoviruses [12]; results were negative.
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