Abstract
The reaction of cis-[RuCl 2(DMSO) 4] with salicylaldehyde semicarbazone in ethanol resulted in the chemoselective cleavage of the C N bond of the Schiff base, forming a complex in which the semicarbazide remains coordinated to the metal, as observed previously with trans-[RuCl 2(DMSO) 4]. In another set of reactions of cis-[RuCl 2(DMSO) 4] with 4-aminoantipyrine derivatives of salicylaldehyde, 2-hydroxy-1-naphthaldehyde and o-vanillin, C N cleavage was observed in all three cases yielding the same compound, [RuCl 2(DMSO) 2(4-aminoantipyrine)]. However, when the reactions, under the same experimental conditions, were extended to unsubstituted/N-substituted thiosemicarbazones of salicylaldehyde and 2-hydroxy-1-naphthaldehyde, no cleavage was observed. All the new complexes were characterized by analytical and spectroscopic techniques. The structures of two of the complexes, [RuCl 2(DMSO) 2(semicarbazide)]·2H 2O and [RuCl 2(DMSO) 2(4-aminoantipyrine)], were determined by single crystal XRD and are in support of the cleavage. The electrochemistry of the complexes was studied by cyclic voltammetry. Further, the preliminary DNA-binding ability and antibacterial activity of the complexes were studied.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
