Abstract
Members of the peroxisome proliferator activated receptor (PPAR) subfamily of nuclear hormone receptors regulate lipid and carbohydrate metabolism in response to the binding of polyunsaturated fatty acids and their metabolites. Several recent studies have revealed an unexpected role of PPARs in the regulation of cholesterol homeostasis in macrophages. These findings could account for some of the antiatherogenic effects of PPAR-γ agonists observed in animal models and have implications for novel approaches to the prevention of atherosclerosis in humans.
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