New role of IgE

Abstract

Rationale To verify existence of extra immunological function of Total IgE. Methods While analyzing the data from the San Francisco Immuno-Personology Project designed for the study of the association between immuno-pathology and personality disorders in individuals with different allergic diseases it was noticed, by complete serendipity, that 57 participants of both genders who happened to be unquestionably creative like opera singers, symphony conductors, professional musicians, actors, published poets, writers, prominent artists, and professional architects, demonstrated different personality disorders associated with Primary IgE Deficiency. Primary IgE Deficiency was defined operationally as a level of Total IgE less than 21 IU/ML. To verify existence of extra-immunological function of IgE, a prospective open-label study was initiated. To-date, that data base consists of 542 creative adults of both sexes (316 females and 226 males). The data were stratified into two distinct not-overlapping groups: 1) artistic creativity and 2) non-artistic creativity as a control group. Results Results showed that artistically creative atopic individuals demonstrated more severe and more frequent Total IgE Deficiency compared to the control group of atopic non-creative patients (p<0.0001). Conclusion This triad of Primary IgE Deficiency, clinically significant Allergy and Artistic Creativity constitute the Creative Syndrome as a distinct clinical entity and demonstrates the existence of the extra-immunological functions of IgE.