Abstract
To understand the cellular context of neuronal differentiation in the vertebrate retina, we analyzed the behavior of a class of progenitor cells in the outer nuclear layer of the teleost retina which divide throughout the animal's life and generate only rod photoreceptors. We present evidence that these progenitors reside adjacent to the outer limiting membrane of the retina during all phases of cell cycle. After final cell division, postmitotic cells move inward, toward the vitreal boundary of the outer nuclear layer, before they give rise to new rods. This movement is remarkable because it occurs in the mature, functioning retina. We hypothesize that only one of the two progenitor daughter cells moves while the other remains adjacent to the outer limiting membrane to divide again.
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