Abstract
The aim of this work is to develop a new low-Tc magnetic implant material with high heat generation and self-controlled capability for hyperthermia treatments based on a new class of Mn1+xTixFe2-2xO4 spinel ferrite. Magnetic Mn1+xTixFe2-2xO4 ferrites were successfully prepared by a coprecipitation technique. The structural and magnetic properties were characterized using X-ray diffraction (XRD), thermomagneto-gravimetric analysis (TMGA), and vibrating sample magnetometer (VSM). The heat generation ability of these magnetic materials was evaluated by calorimetric measurements of specific absorption rate (SAR). XRD results demonstrated an increase in the lattice constant of Mn-ferrites with increasing Ti content, whereas showed a tendency to decrease linearly with increasing Ti content in the Mn-ferrite. Tc was confirmed to be tunable within the therapeutic temperature range by adjusting the Ti4+ content near x = 0.55. These behaviors could be explained by considering the lattice expansion in the spinel structure of Mn-ferrites, which was accompanied by a decrease in the overlap of orbital and the JA-B superexchange interaction. The SAR value obtained was about 17.5 W/g with a maximum self-controlled temperature within the safe therapeutic range (42-46°C). MTT (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay results confirmed that the toxicity of bare ferrite particles was related to the particle concentration. The cell viability showed a decrease from 93% to 66% with increasing particle concentration from 0.05 to 10 mg/ml. The high saturation magnetization and SAR of Mn1.55Ti0.55Fe0.9 along with tunability of its Curie temperature in the therapeutic temperature range, and its relatively low cytotoxicity rendered this new magnetic material attractive for hyperthermia therapy applications in comparison with other Tc-tuned spinel ferrites.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.