Abstract
IntroductionThe use of saline irrigation for nasal washes is a well established procedure in the treatment of sinonasal inflammation and infection. In addition to saline solutions, Ringer's lactate is also an efficient option for nasal washes and humidification. ObjectiveTo assess the comfort, humidification and tolerance regarding stinging sensation, provided by sodium chloride nasal gel at the concentrations of 4.5mg/g and 6.0mg/g through questionnaires answered by the patients. MethodsA total of 60 patients, 56 females, aged between 22 and 66 years old (mean age of 47) and 4 males, aged between 36 and 66 years (mean age of 49), were included in the study for a period of 17 days (±2 days) treatment. The patients were monitored by a general practitioner throughout the study period. They were instructed to apply each product in both nostrils twice a day during a 7-day period (±2 days). The patients were evaluated prior to the use of the first product at visit 0 (V0), after 7 days of treatment (±2 days) at visit 1 (V1), after 3 days of product discontinuation at visit 2 (V2) and after 7 days (±2 days) of treatment with the second product, in visit 3 (V3). ResultsA significant difference (5% significance) was observed regarding comfort and stinging sensation between the two different concentrations; comfort was higher and stinging was lower with the 6.0mg/g concentration gel. No difference in humidification was observed between the two treatments. ConclusionRinger's lactate at the concentration of 6.0mg/g was superior to that at 4.5mg/g for parameters comfort and stinging sensation. No statistical difference was observed between the two products regarding nasal humidification.
Highlights
Inflammatory conditions of the nose and paranasal sinuses are the most prevalent group of diseases in the general population
This study aims to compare the tolerability and the efficacy of nasal hydration between sodium chloride nasal gel at 4.5 mg/g and Ringer’s lactate nasal gel at 6.0 mg/g
The enrolled sample consisted of patients with recommendation of nasal gel application, who met the inclusion
Summary
Inflammatory conditions of the nose and paranasal sinuses are the most prevalent group of diseases in the general population. Allergic and non-allergic rhinitis, as well as acute and chronic rhinosinusitis, result in a marked decrease in quality of life and generate significant losses in labor productivity, leisure and social activities in general.[1]. Nasal topical medications are extremely important in the treatment of inflammatory and infectious nasal and paranasal sinus diseases, allowing active substances to reach the targeted site in order to exert their clinical local action, minimizing the systemic effects.[1]. The use of saline solution for nasal hygiene has been recommended by many experts in rhinology, and its effect may be greater than just that of an adjuvant treatment.[1]
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