New reverse transcriptase inhibitors.

Abstract

Reverse transcriptase inhibitors used in the treatment of HIV-1 infection include the nucleoside analogues zidovudine, didanosine, zalcitabine, lamivudine and stavudine. More recently a number of other classes of reverse transcriptase inhibitors have been discovered, and are in various phases of clinical trial. This chapter will focus on the nucleoside analogue abacavir or 1592U89, the non-nucleoside analogues MKC-442, nevirapine, delavirdine, loviride, efavirenz or DMP 266, and the nucleotide analogues adefovir dipivoxil or bis-pom PMEA, and bis-poc PMPA (Table 1).