Abstract
New data for the ${}^{\text{nat}}\mathrm{V}(p,x)$ reactions have been measured in the range 26--70 MeV, with production of the nuclides $^{47}\mathrm{Sc}, ^{43}\mathrm{Sc}, {}^{44m}\mathrm{Sc}, {}^{44g}\mathrm{Sc}, ^{46}\mathrm{Sc}, ^{48}\mathrm{Sc}, ^{42}\mathrm{K}, ^{43}\mathrm{K}, ^{48}\mathrm{V}, ^{48}\mathrm{Cr}, ^{49}\mathrm{Cr}$, and $^{51}\mathrm{Cr}$. The focus is on the production of $^{47}\mathrm{Sc}$, a ${\ensuremath{\beta}}^{\ensuremath{-}}$ emitter suitable for innovative radiotheranostic applications in nuclear medicine. The measured cross sections for this radionuclide and its contaminants are compared with the theoretical excitation functions calculated with the talys code. In view of novel radiopharmaceutical applications, it is essential to accurately describe these cross sections for the evaluation of yields, purities, and dose releases. Hence, we optimize the level-density parameters of the microscopic models in the talys code to obtain the best possible descriptions of the new data. We consider different irradiation conditions to estimate the production yields from the cross sections determined in this paper.
Highlights
The theranostic radionuclide 47Sc has gained the attention of the scientific community for its favorable decay characteristics (T1/2=3.35 d, Eβ− =162 keV, Eγ =159 keV, I = 68.4%) [1] that make it one of the most attractive radionuclides for nuclear medicine applications [2]
The project was developed in the framework of the LAboratory of RAdionuclides for MEDicine (LARAMED) program at the Istituto Nazionale di Fisica Nucleare (INFN) Legnaro National Laboratories (LNL), where a 70-MeV proton cyclotron was installed and the infrastructure for nuclear cross-section measurements and small-scale production of medical radionuclides for preclinical applications is under completion [9]
III, we illustrate the main considerations upon the models implied by the nuclear reaction code TALYS, and how we have used the nuclear levels density (NLD) parameters to optimize the reproduction of the measured cross sections
Summary
For this reason, all possible 47Sc product ion routes are investigated worldwide, considering both accelerators (cyclotrons and LINear ACcelerator) and nuclear reactors. The PASTA project (acronym for Production with Accelerator of Sc-47 for Theranostic Applications) aimed at measuring the most promising nuclear reactions to produce 47Sc considering proton beams [7,8]. The project was developed in the framework of the LAboratory of RAdionuclides for MEDicine (LARAMED) program at the Istituto Nazionale di Fisica Nucleare (INFN) Legnaro National Laboratories (LNL), where a 70-MeV proton cyclotron was installed and the infrastructure for nuclear cross-section measurements and small-scale production of medical radionuclides for preclinical applications is under completion [9]
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