Abstract
It is well known that optical resolution via crystallization is still auseful and practicalmethod for obtaining enantiomerically pure compounds for both laboratory experiment and industrial production,although it is aclassical technique discovered nearly 160years ago. In particular, diastereomericsalt formation using aresolving agent (diastereomer method) has been well applied in various fieldssuch as the pharmaceutical, agrochemical, and liquid crystal industries. Despite these affluent reportedand patented examples, unfortunately no concrete theory to determine an optimum resolution condition hasbeen devised, and only empirical procedures seem to provide aunique path in process development. Inthis chapter, three novel approaches for optical resolution via diastereomeric salt formation are presented:(1)chiral purity improvement by crystal habit modification with atailored chiral additive; (2)anewapproach for finding asuitable resolving agent based on the space filler concept; and (3)chiralitycontrol by dielectrically controlled resolution.
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