Abstract
The conversion of alcohol to alkyl halide in the presence of triphenylphosphine and carbon tetrahalide, which is commonly known as the Appel reaction, is an important route for halogenations under mild and neutral conditions. During the past twenty years, the Appel reaction has experienced a considerable evolution. Several convenient reagents have been developed and applied as electrophilic halogen sources despite a decline in the use of carbon tetrahalides. In addition, modified Appel-type reactions allow for the synthesis of alkyl halides as well as thiocyanates, nitrates, nitrites, amides, esters and acyl halides. Different synthetic methodologies to reduce the byproduct waste from the Appel reaction have been reported in the literature and are presented in this paper. Herein, this review will present recent achievements in the use of novel reagents and synthetic procedures for Appel-type reactions Keywords: Alcohols, appel reaction, halides, halogenation, N-halo reagents, triphenylphosphine
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
