New progresses of causes and pathogenesis of bronchial asthma

Abstract

The current study shows that the disorders of the Th1/Th2's immune function play an important role in the pathogenesis of bronchial asthma (asthma).Recently,growing evidence demonstrates that the pathogenesis of asthma is related with many factors.Among them,cigarette smoking is a well-known risk factor for the onset of athma.Th17 cells and its related cytokines play crucial roles in the development of asthma.Interleukin-33 plays a crucial role in the pathogenesis of asthma.MicroRNA play an important role in the regulation of genes expression post-transcriptionlly,and they also modulate growth of cells and development of organs.Bone morphogenetic proteins participate in the process of fibrosis in many tissues.Gremlin is an inhibitor of BMPs.It provide new thinking for the investigation of pathogenesis and treatment of asthma that summarize the expression and efffec of BMPs and gremlin in asthma.Adipocyte fatty acid binding protein may play an important role in asthma. Key words: Smoking; T17 helper cells; Interleukin-33; MicroRNA; Bone morphogenetic proteins; Adipocyte fatty acid binding protein; Bronchial asthma