New Progress in the Design, Synthesis and Application of Fluorescent Probes for Fluoride Ion Detection

Abstract

The recognition and detection of trace fluoride ions in vivo and vitro have attracted great attention in recent years. More and more new fluorescent probes (FP) for fluoride ion detection have been designed and synthesized due to their advantages, such as high sensitivity, good selectivity and convenient operation. According to the different structural features and recognition mechanism, fluoride ion FP can be classified into two catego- ries as deprotonation and reaction type. The new progress especially in recent three years on their molecular de- sign, synthesis and application are reviewed on the viewpoint of green chemistry. The future trend of fluoride ion FP is also prospected. Keywords Fluoride ion; Fluorescent probe; Molecular design; Synthesis; Green chemistry