Abstract
The Prognostic Inflammatory and Nutritional Index (PINI) was previously developed to improve the diagnosis and monitoring of patients with inflammation and/or malnutrition in terms of morbidity and mortality risk, especially in ICU patients [1]. The formula includes the determination of four serum protein concentrations: PINI = (C-reactive protein (CRP) (mg/l) × orosomucoid (OROSO) (g/l))/(albumin (ALB) (g/l) × transthyretin (TTR) (g/l)). Since CRP may be considered now as the gold standard for assessing and monitoring inflammatory states in clinical practice, OROSO is generally unavailable for PINI calculation. Elsewhere, the strong and rapid changes in CRP levels (0 to 600 mg/l) in acute inflammation may lead to an overestimation of the risk of morbidity and mortality suggested by the PINI. The aim of this study was to evaluate alternative biological formulas by removing OROSO from the PINI and replacing CRP value by its logarithm (Log), in order to reduce the mathematical weighting of this biomarker.
Highlights
In this study we aimed to investigate the relationship between thyroid hormone abnormalities and major cardiovascular events and sudden cardiac death at 3 and 6 months after discharge in patients who were admitted to the Emergency Department with acute coronary syndrome
The aim of this study was to demonstrate the role of arginase and adenosine deaminase (ADA) in patients suffering from myocardial infarction (MI), and in a group of patients with chronic renal failure (CRF) with cardiovascular diseases (CVD)
ADA may be considered good diagnostic enzymes in patients suffering from MI, and ADA for patients with CRF with CVD
Summary
Results We studied 53 patients (42 males, mean age (SEM) 57.6 (2.8) years, illness severity scores APACHE II 21.3 (0.9); SAPS II 53.3 (2.3); SOFA 10.2 (0.2); and ICU stay 35.9 (4.8) days). Results We included 53 consecutive patients (42 males, mean age 57.6 ± 2.8 years, illness severity scores APACHE II 21.3 ± 0.9; SAPS II 53.3 ± 2.3; SOFA 10.2 ± 0.2; and mean ICU stay 35.9 ± 4.8 days) of which 25 (47.2%) had at least one US findings. The objective of this study was to determine the incidence and type of incidents related to intrahospital transport (IHT) of critically ill patients in our ICU and to identify contributing factors of these incidents. The aim of this study was to assess the effect of monotherapy with nebulized colistin on clinical and microbiological outcomes in critically ill patients with VAT due to polymyxin-only susceptible Gram-negative bacteria
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