Abstract
We recently developed a new monkey model complicating chronic atrioventricular conduction block. In this study, we compared anatomical, neurohumoral and proarrhythmic profiles of the atrioventricular block monkeys with those of normal animals. The cynomolgus monkeys of either sex (3–5 kg) were used (n=12). The atrioventricular node of the 6 animals was ablated under anesthesia, and their anatomical, neurohumoral and proarrhythmic profiles were assessed more than 2 months after the surgery. The cardiothoracic ratio of the chronic atrioventricular block monkeys was 59±1% (n=6), which was greater than that of the normal group (47±1%, n=6, p<0.001).
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