Abstract
The novel cucurbitacins, balsaminagenin A and B ( 1– 2) and balsaminoside A ( 3) and the know cucurbitacin karavelagenin C ( 4), together with five new mono or diacylated derivatives ( 5– 9) of karavelagenin C were evaluated for multidrug resistance reversing activity on human MDR1 gene transfected mouse lymphoma cells. Compounds 2– 6 exhibited a strong activity compared with that of the positive control, verapamil. Structure–activity relationships are discussed. Moreover, in the checkerboard model of combination chemotherapy, the interaction between doxorubicin and compounds 2– 5 synergistically enhanced the effect of the anticancer drug. Compounds 1– 4 were isolated from the aerial parts of Momordica balsamina L . The structures of the compounds were established on the basis of spectroscopic methods including 2D NMR experiments (COSY, HMQC, HMBC and NOESY).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.