Abstract
ABSTRACTAging is an inevitable process influenced by genetic, lifestyle, and environmental factors. Indirect evidence shows that several phytochemicals can have anti-aging capabilities, although direct evidence in this field is still limited. This report aims to provide a critical review on aspects related to the use of novel phytochemicals as anti-aging agents, to discuss the obstacles found when performing most anti-aging study protocols in humans, and to analyze future perspectives. In addition to the extensively studied resveratrol, epicatechin, quercetin, and curcumin, new phytochemicals have been reported to act as anti-aging agents, such as the amino acid L-theanine isolated from green tea, and the lignans arctigenin and matairesinol isolated from Arctium lappa seeds. Furthermore, this review discusses the application of several new extracts rich in phytochemicals with potential use in anti-aging therapies. Finally, this review also discusses the most important biomarkers to test anti-aging interventions, the necessity of conducting epidemiological studies and the need of clinical trials with adequate study protocols for humans.
Highlights
Critical Reviews in Food Science and NutritionISSN: 1040-8398 (Print) 1549-7852 (Online) Journal homepage: http://www.tandfonline.com/loi/bfsn
Aging is a complex biological process characterized by a gradual loss of physiological integrity, leading to the decline of almost all physiological functions and increased vulnerability to death (Lopez-Otın et al, 2013; Lenart and Krejci, 2016)
It has been proposed that humans age in “spare parts”, a process characterized by increasing losses of vital functions, some occurring faster, as the elastic functions, and others relatively slowly, as the nervous conductivity (Labat-Robert and Robert, 2014)
Summary
ISSN: 1040-8398 (Print) 1549-7852 (Online) Journal homepage: http://www.tandfonline.com/loi/bfsn. New phytochemicals as potential human anti-aging compounds: Reality, promise, and challenges. Accepted author version posted online: 13 Sep 2016.
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