Abstract
Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1–5, named chukbularisins A–E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro α-glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against α-glucosidase with IC50 values of 0.06 ± 0.008, 0.04 ± 0.002, 0.52 ± 0.039, 1.09 ± 0.040, and 0.20 ± 0.057 mM, respectively (using acarbose as positive control, IC50 0.95 ± 0.092 mM).
Highlights
The genus Chukrasia (Meliaceae) comprising only Chukrasia tabularis A
The EtOAc-soluble extract of the stems of C. limonoids tabularis was subjected to repeated chromatography to afford five new phragmalin-type
The results showed that compounds 2, 3, 4, 5, and 8 exhibited α-glucosidase inhibitory activity with IC50 values of 0.06 ̆ 0.008, 0.04 ̆ 0.002, 0.52 ̆ 0.039, 1.09 ̆ 0.040, and 0.20 ̆ 0.057 mM, respectively (Table 4), among which compound 3 is 24 times more potent than the positive control
Summary
The genus Chukrasia (Meliaceae) comprising only Chukrasia tabularis A. Velutina, which are mainly distributed in the tropical areas of Asia, such as India, Malaysia, and southern China [1]. C. tabularis is a timber tree, which is widely cultivated in southern China for the use of urban afforestation and pot culture because it is an evergreen tree. This study was focused on the isolation and identification of new bioactive limonoids from. C. tabularis showed significant α-glucosidase inhibitory activity. Subsequent chemical investigation led to the identification of five new phragmalin-type limonoids 1–5 that we have named chukbularisins. Compounds 2, 3, 4, 5, and 8 showed inhibitory activities against α-glucosidase. To the best of our knowledge, the α-glucosidase inhibitory activity.
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