Abstract
Six new phenolic derivatives, including four flavonoids and two benzofuranones, were isolated from the aerial part extracts of Vernonia mapirensis Gleason (synonymous Lepidaploa mapirensis (Gleason) H. Robinson, Vernonia trichoclada Gleason, Asteraceae family), together with four known flavonoids. Their structural elucidation was achieved by extensive spectroscopic methods, 1D- ( 1 H, 13 C, 13 C DEPT, TOCSY, ROESY) and 2D-NMR experiments (DQF-COSY, HSQC, HMBC) as well as ESI-MS analysis.
Highlights
Vernonia genus (Asteraceae family) comprises tropical and sub-tropical species widespread through both the hemispheres.1 Previous phytochemical studies on this genus led to the isolation and characterization of flavonoids, steroidal glycosides, and sesquiterpenes.2-5 In our continuing studies on the chemistry of Vernonia species, we selected V. mapirensis Gleason (synonymous Lepidaploa mapirensis (Gleason) H
The aim of our work was to carry out the phytochemical investigation of V. mapirensis aerial parts and we report the isolation and structural characterization of six new phenolic derivatives, including four flavonoids [1,2,3,4] and two benzofuranones [5,6], from the methanol and chloroform-methanol extracts of the title plant, on the basis of extensive spectroscopic and spectrometric analysis (1D-NMR, 2D-NMR, ESI-MS)
Its molecular formula was established as C36H36O19 by means of ESI-MS ([M-H]- peak at m/z 771), 13C, 13C-DEPT NMR, and elemental analysis
Summary
Vernonia genus (Asteraceae family) comprises tropical and sub-tropical species widespread through both the hemispheres.1 Previous phytochemical studies on this genus led to the isolation and characterization of flavonoids, steroidal glycosides, and sesquiterpenes.2-5 In our continuing studies on the chemistry of Vernonia species, we selected V. mapirensis Gleason (synonymous Lepidaploa mapirensis (Gleason) H. All the 1H- and 13C-NMR signals of 1 were assigned using 1D-TOCSY, DQF-COSY, HSQC, and HMBC experiments. Table 2: 1H- and 13C-NMR data of compounds 3-4 (CD3OD, 600 MHz)a
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