New perspectives from South-Y-East, not all about death. A report of the 12th lnternational Meeting on Yeast Apoptosis in Bari, Italy, May 14th-18th, 2017.

Nicoletta Guaragnella,Sergio Giannattasio,Joris Winderickx,Campbell Gourlay,Paula Ludovico,Frank Madeo,Cristina Mazzoni,Manuela Corte-Real,William Burhans,Mariarita Stirpe,Dina Petranovic

doi:10.15698/mic2018.02.616

Abstract

New perspectives from South-Y-East, not all about death. A report of the 12th lnternational Meeting on Yeast Apoptosis in Bari, Italy, May 14th-18th, 2017.

Highlights

The identification of certain death-resistant deletion strains through a genome wide screen analysis in Saccharomyces cerevisiae
Campbell Gourlay (UK) presented results on the conserved link between environmental signals, cytoskeletal integrity and cell fate control. He showed that defects in actin regulation lead to the inability to control the fidelity of MAPK signaling pathways. He observed that the yeast filamentous growth and mating MAPK pathways become inappropriately activated in response to a reduction in actin dynamics and that actin stabilization leads to the constitutive activation of the MAPK controlled cell wall integrity pathway
He observed that the de-regulation of MAPK signaling leads to vacuole dysfunction, ROS production and cell death that can be reversed by porin deletion

Summary

Introduction

The identification of certain death-resistant deletion strains through a genome wide screen analysis in Saccharomyces cerevisiae. * Corresponding Authors: Sergio Giannattasio, Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, CNR, Bari, Italy; E-mail: s.giannattasio@ibiom.cnr.it; Cristina Mazzoni, Pasteur Institute-Cenci Bolognetti Foundation, Department of Biology and Biotechnologies “C.

Results

Conclusion