New pentacoordinated Schiff-base diorganotin(IV) complexes derived from nonpolar side chain α-amino acids

Abstract

In this work we report the synthesis and spectroscopic characterization of twenty new pentacoordinated diorganotin(IV) compounds. These compounds have been prepared in good yields by multicomponent reactions (MCRs) of α-amino acids (isoleucine, leucine, methionine, phenylalanine and aminophenylacetic acid), 2,4-dihydroxybenzaldehyde, 2-hydroxy-4-methoxybenzaldehyde and either di- n-butyltin(IV) oxide or diphenyltin(IV) oxide. All compounds were characterized by IR spectroscopy, 1H, 119Sn and 13C NMR spectroscopy and mass spectrometry. Each compound has a coordinative N→Sn bond and shows the expected 119Sn NMR chemical shift indicative of a pentacoordinated or hexacoordinated tin atom in CDCl 3 and DMSO-d 6, respectively. These compounds were also tested in tumoral cell lines, HeLa, HCT-15 and MCF-7, in order to evaluate the antiproliferative activity and to obtain the medial inhibitory concentrations (IC 50) values.