New Pd(II) complexes containing hydrazinyl oxazolyl coumarin derivatives: synthesis, spectral characterization and anti-cancer studies

Abstract

Abstract New palladium(II) complexes containing coumarin derivatives such as (E)-3(2-(2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazinyl)oxazol-4-yl)-2H-chromen-2-one (HL 1 ), (E)-7-hydroxy-3(2-(2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazinyl)oxazol-4-yl)-2H-chromen-2-one (HL 2 ) were successfully designed and synthesized from the reaction of K2[PdCl4] with ligands HL 1&2 with in Methanol medium. The ligands and complexes were characterized by various analytical and spectral techniques such as FT-IR, UV–Vis, 1H NMR and 13C NMR spectral techniques. From the spectral data we confirmed that the ligands neutrally coordinated with Pd(II) ion via their lactone oxygen, azomethine nitrogen and oxazolyl ring nitrogen atoms. The electrolytic nature of the complexes was confirmed by using conductivity experiments. Further anticancer activity of the compounds has examined with HeLa (human cervical cancer) cells along with the cisplatin as positive control and the obtained results revealed that the complexes possess significant anticancer activity and non-toxic towards HUVEC (human umbilical vein endothelial) cells.