Abstract
A string of four new hetero binuclear Ru(III) complexes of ferrocenecarboxaldehyde‐4(N)‐substituted thiosemicarbazones were synthesized and characterized by various spectral (infrared, ultraviolet–visible, Electron Paramagnetic Resonance (EPR) and High Resolution Mass Spectrometry (HR‐MS) techniques. The binding abilities of the ligands/complexes with nucleic acid (calf thymus DNA, CT‐DNA) and bovine serum albumin (BSA) were analyzed by absorption and emission titration methods. The complexes exhibited better DNA binding affinity than their parent ligands. The interaction with CT‐DNA was found to be intercalative and with BSA static quenching mechanism was observed. All the synthesized Ru(III) complexes were subjected to study their in vitro cytotoxicity against MCF‐7 (human breast cancer) and HT‐29 (human colon cancer) cell lines. Among the four complexes, complex 3 [RuCp (FF‐etsc)PPh3]Cl exhibited the highest cytotoxicity in MCF‐7 cells and complex 4 [RuCp (FF‐ptsc)PPh3]Cl was the most active on HT‐29 cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
