Abstract
Chronic obstructive pulmonary disease (COPD) induces atrial fibrillation (AF) and stroke, and COPD with AF increased ischemic stroke (IS) in a cross-sectional study. Therefore, healthcare providers must be concerned and well-informed about this particular situation. For this study, inpatient data were obtained from the Taiwan National Health Insurance Database in 2010. We identified patients who were hospitalized with COPD (International Classification of Disease, Ninth Revision, Clinical Modification [ICD-9-CM] is 491, 492, and 496). Patients who experienced AF (ICD-9-CM to 427.3) during the same admission or after COPD hospitalization were discharged and defined as new-onset AF. The outcome was IS (ICD-9-CM as 433–437). The factors related to IS after COPD were used for multivariate logistic regression. There were 4177/62,163 (6.72%) patients with incident IS. The risk of IS after COPD hospitalization was shown to have an adjusted odds ratio of 1.749 (95% CI: 1.584–1.93, p < 0.001) for patients with new-onset AF. Other factors included advanced age, atherosclerosis factors, comorbidity severity, sepsis and lower-level hospital admission. In conclusion, COPD patients suffering from new-onset AF had an increased incidence of IS in the population observation study. New-onset AF was an omit risk factor for IS in COPD in the Chinese population.
Highlights
Chronic obstructive pulmonary disease (COPD) is a persistent and progressive airflow limitation
There were 62,163 COPD patients evaluated after exclusion of 9131 patients; 5235 (8.42%) had new-onset atrial fibrillation (AF) and 4177 (6.72%) had incident ischemic stroke (IS)
Our study showed that COPD followed by new-onset AF increased IS occurrence
Summary
Chronic obstructive pulmonary disease (COPD) is a persistent and progressive airflow limitation. COPD may limit activity, affect quality of life, and lead to disability. The number of patients with COPD has increased to 384 million, and the international prevalence rate is 11.7%. The overall prevalence in men ≥30 years old is 14.3% compared with 7.6% in women [1]. The most important risk factors for COPD are smoking, advanced age and environmental pollution. Acute exacerbation results in the overall severity of the condition, leading to an accelerated decline in lung function with significant mortality
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