Abstract
The 5'-O-(4,4'-dimethoxytrityl)-2'-O-(trialkylsilyl) ribonucleoside 3'-O-(2-cyanoethyl N,N-diethylphosphoramidites) modified monomers for RNA synthesis, were prepared from 2-cyanoethyl N,N-diethylchlorophosphoramidite. In conjunction with newly developed coupling protocols for automated solid-phase synthesis, they afforded synthetic oligoribonucleotides up to 74 base units in length. Purification procedures by reverse phase HPLC and PAGE methods are also presented
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