Abstract
Two new dibenzylbutane lignans, namely rel-methyl (2S)-2-hydroxy-2-2′-((2″R,3″R)-4″-guaiacyl-2″,3″dimethylbutyl)-5′-oxo-2′,5′-dihydro-2-furanylethnoate (1) and rel-methyl (2S)-2-hydroxy-2-2′-((2″R,3″S)-4″-guaiacyl-2″,3″dimethylbutyl)-5′-oxo-2′,5′-dihydro-2-furanylethnoate (2), were isolated from the bark of Machilus thunbergii. Their structures were elucidated by spectral analysis. These two lignans exerted significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells. Compounds 1 and 2 represent a new type of lignan skeleton that has not been reported so far from nature.
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