New nanostructured apatite-type (Na+,Zn2+,CO32−)-doped calcium phosphates: Preparation, mechanical properties and antibacterial activity

Abstract

Nanoparticles with the sizes in the range (20–30) nm of apatite-type Na+,Zn2+,CO32−-doped calcium phosphates were prepared from aqueous solution of Na+-Ca2+-Zn2+-NO3−-CO32−-PO43- system at molar ratios Ca2+/PO43- =1.67, CО32−/РО43- = 1, Zn2+:Ca2+ = 1:100 or 2:100. The elemental analysis showed growth of Zn2+ content in composition of samples from 0.61 to 1.95 wt% at increasing of Zn2+ amount in an initial solution. According to FTIR and Raman data, B-type substitution of PO43− by CO32− realized in apatite-type calcium phosphates. The mechanical properties study for prepared phases showed the dependence of Young's modulus and compressive strength on Zn2+ amount in their composition. Growth of S. epidermidis after the contact with synthesized apatite containing Na+ (0.25 wt%), Zn2+ (0.61 wt%) and CO32− (1.18 wt%) was significantly delayed with an extension of lag time from 1 to 13–14 h. The prepared sample can be considered as a new prospective biomaterial with antibacterial potential.