Abstract
The nanosized systems involving Pt(IV) complexes with antitumor activity are obtained by their solubilization via amphiphilic copolymers of N-vinylpyrrolidone and (di)methacrylates synthesized by the radical copolymerization in toluene without any polymer chain growth terminating agents. The resulting systems are investigated by a complex of physico-chemical methods (IR spectroscopy, DLS, TEM, cyclic and square-wave voltammetry) and quantum chemical simulation. The Pt(IV) complexes are shown to have cytotoxic effects on A-172 tumor cells and the corresponding cytotoxicity indices (IC50) are determined. The amphiphilic copolymers under consideration are promising modern platforms and delivery vehicles for biologically active compounds.
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