Abstract
In this paper, two types of porous clay heterostructures were proposed as drug delivery systems for loading of methotrexate (MTX), an antitumor drug used to treat a wide range of diseases. The inorganic porous heterostructured materials, characterized by different textural properties, morphologies and structural properties were synthesized using a montmorillonite as starting clay in which silica precursor was polymerized in various conditions. The properties of porous materials were evaluated by various techniques (FTIR, XPS, XRD, elemental analysis, zeta potential, TEM, BET analysis and UV-VIS). BET results suggested that these materials exhibit superior textural properties than starting clay used in the synthesis. The drug encapsulation efficiency of inorganic hosts was influenced by the textural properties. TEM and XRD analysis indicated that the inorganic hosts were characterized by a highly intercalated-exfoliated structures. The prepared MTX delivery systems were characterized by different drug release profiles that are strongly influenced by the PCHs properties. The proposed inorganic hosts are opening the path for a new type of drug delivery systems. The high encapsulation efficiency, textural and structural properties recommend these types of materials as a potential nanostructured host for methotrexate drug.
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