New Nano-Bioactive Glass/Magnesium Phosphate Composites by Sol-Gel Route for Bone Defect Treatment

Abstract

This work was mainly aimed to synthesize new ceramic composites based on nano-bioactive glass (nBG) and magnesium phosphate ceramic (MgP) with different ratios using the sol-gel approach in order to overcome the limitations of both materials. The glass was based on 85SiO2-10CaO-5P2O5 (mole %), and MgP was based on the formula; Mg3(PO4)2. The obtained composites were characterized by DTA, XRD, FTIR, SEM/EDX and Zeta potential techniques. The in vitro bioactivity test was carried out in SBF, and the cell viability test was conducted by culturing the composites with human normal fibroblast cell line (BJ1). The results of XRD analyses showed that there were often no strong diffraction peaks detected which indicated the amorphous nature of the ceramic composites. Moreover, soaking of the ceramic composites in SBF exhibited that addition of MgP to nBG was increased the degradation of the latter one, and nBG was improved the formation of apatite crystals on MgP ceramic. Moreover, the cell viability results showed that MgP was showed significant higher viability than nBG at high concentrations, and it improved the viability of nBG in the ceramic composites.