Abstract
A new 1:1 molecular complex of triterpene glycoside ammonium glycyrrhizate (GC) with flavonoid glycoside rutin (Rut) was obtained in aqueous ethanol. The stability constant (9.7±0.2)×104 (mol/L)–1 was calculated for the complex via isomolar curves. The complexation was studied by UV- and ATR IR-Fourier spectroscopy and a method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex. A preliminary antioxidant activity assessment of the complex was made.
Highlights
Rutin (Rut; Fig. 1) is one of the most famous flavonols and glycosides [1]
The study [2] showed that the solubility and bioavailability of bioactive compounds can be significantly increased by their molecular complexation with triterpene glycosides
Triterpene saponins are amphiphilic multidentate ligands that are capable of molecular complexation with both polar and non-polar fragments of other molecules [2]
Summary
Rutin (Rut; Fig. 1) is one of the most famous flavonols and glycosides [1]. Rut has a low solubility in water and limited membrane permeability [1]. The therapeutic effect of Rut is limited due to its bioavailability [1]. The study [2] showed that the solubility and bioavailability of bioactive compounds can be significantly increased by their molecular complexation with triterpene glycosides. Triterpene saponins are amphiphilic multidentate ligands that are capable of molecular complexation with both polar and non-polar fragments of other molecules [2]. GA increases permeability of cell membranes [5]. We studied the molecular complex of quercetin with GC [6]. Molecular complexes of Rut with GC have not been described. This article reports the preparation of a new molecular complex of GC with Rut
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