Abstract
New models to investigate complex glucocorticoid receptor functions
Highlights
The main finding of this study is that mutant zebrafish larvae with impaired glucocorticoid receptor (GR) transactivation, due to a single nucleotide substitution in a region essential for DNA binding, exhibit behavioral abnormalities and neuroendocrine dysfunction
The authors test whether the selective serotonin reuptake inhibitor (SSRI) antidepressant, fluoxetine, is able to reverse the neuroendocrine and behavioral phenotype of grs357 mutants
Their findings suggest that fluoxetine does not reverse neuroendocrine abnormalities resulting from impaired GR transactivation, while it still effectively counteracts anxiety-like behavior
Summary
The significance of the glucocorticoid receptor (GR) in stress response regulation and mood disorders has been demonstrated by many studies in animal and human models (Anacker et al, 2011a). The paper by Griffiths’ and colleagues adds to this evidence, by investigating GR function and its role in stress response regulation and antidepressant action in an exciting new zebrafish model.
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