Abstract
So far as I know there are two methods of testing cough depressing drugs. In Ernst's method (1) Lugol's solution is injected into one of the pleural cavity of a cat to cause a state of cough readiness. Another is Eichler-Smiatek's (2), in which cough attacks are brought about in a guinea pig by spraying. sulphuric acid into a compartment in which the animal is kept. These methods, however, are not effectual enough to cause cough attacks constantly at the desired time, and can hardly be employed for evaluation of cough remedies. I therefore have devised two methods. Method 1 is to apply mechanical stimulation to the mucous membranes of the air passages to cause a fit of coughing ; method 2 is to apply electric stimulation to the sensory nerve branch of the trachea.
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