New Method for Preparing Small-Caliber Artificial Blood Vessel with Controllable Microstructure on the Inner Wall Based on Additive Material Composite Molding.

Junchao Hu,Weixia Lan,Tao Yue,Zhian Jian,Na Liu,Chunxiang Lu,Yuanyuan Liu

doi:10.3390/mi12111312

Abstract

The diameter of most blood vessels in cardiovascular and peripheral vascular system is less than 6 mm. Because the inner diameter of such vessels is small, a built-in stent often leads to thrombosis and other problems. It is an important goal to replace it directly with artificial vessels. This paper creatively proposed a preparation method of a small-diameter artificial vascular graft which can form a controllable microstructure on the inner wall and realize a multi-material composite. On the one hand, the inner wall of blood vessels containing direct writing structure is constructed by electrostatic direct writing and micro-imprinting technology to regulate cell behavior and promote endothelialization; on the other hand, the outer wall of blood vessels was prepared by electrospinning PCL to ensure the stability of mechanical properties of composite grafts. By optimizing the key parameters of the graft, a small-diameter artificial blood vessel with controllable microstructure on the inner wall is finally prepared. The corresponding performance characterization experimental results show that it has advantages in structure, mechanical properties, and promoting endothelialization.

Highlights

Susana Catarino and Graça MinasThe incidence and mortality of cardiovascular diseases have been showing an upward trend year by year, which seriously affects human health [1]
The angle formed by the line, if the contact angle is greater than 90◦, the material is judged to be hydrophobic, the larger the angle, the higher the hydrophobicity; if the contact angle is less than 90◦, the material is judged to be hydrophilic, and the smaller the angle is, the material is judged to be hydrophilic
In the in vitro cell culture experiment, additional pcl gelatin direct writing composite group samples were added for control

Summary

Introduction

Susana Catarino and Graça MinasThe incidence and mortality of cardiovascular diseases have been showing an upward trend year by year, which seriously affects human health [1]. In order to allow the artificial blood vessel to fuse with the host blood vessel after being transplanted into the body, and to quickly achieve the metabolic function of the natural blood vessel, the construction of a small-caliber artificial blood vessel must meet the bionic structure and mechanical properties, and achieve rapid and effective endothelialization. This poses a challenge to both the material design and preparation process [11,12]. There are few studies that combine this type of research

Methods

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Discussion

Conclusion