Abstract
A sensitivity-turbidimetric method at (0-180o) was used for detn. of mebeverine in drugs by two solar cell and six source with C.F.I.A... The method was based on the formation of ion pair for the pinkish banana color precipitate by the reaction of Mebeverine hydrochloride with Phosphotungstic acid. Turbidity was measured via the reflection of incident light that collides on the surface particles of precipitated at 0-180o. All variables were optimized. The linearity ranged of Mebeverine hydrochloride was 0.05-12.5mmol.L-1, the L.D. (S/N= 3) (3SB) was 521.92 ng/sample depending on dilution for the minimum concentration, with correlation coefficient r = 0.9966while was R.S.D% < 1% of 2, 6 mmol.L-1 conc. of Mebeverine hydrochloride. The method is used successfully for three different of target drugs in three different pharmaceutical formulations. A comparison using t-test was studied. It was shown that there is no significant difference between two values.
Highlights
Mebeverine hydrochloride (MVH), 3,4-dimethoxybenzoic acid 4-[ethyl-2-(4- methoxyphenyl)-1-aminobutylveratrate hydrochloride, Fig. 1, is a nonspecific antispasmodic agent which acts directly on the smooth muscle of the gastrointestinal tract (1).Turbidimetry is defined as the measurement of the degree of attenuation of a radiant beam incident on suspended particles in solution.Nephelometry is the scattered measurement of the light by suspended particles, usually carried out at 90o (2)
Several analytical methods have been developed for the determination of Mebeverine Hydrochloride in lecturer review, Mebeverine Hydrochloride was determined by high performance liquid chromatography (HPLC) (7-10), Spectrophotometric (11-14)
Analysis of the Drug The established method was used for MVH in three kinds of 135 mg MVH from three manufactures (Mevir- Microlabs-India), (MevaJamjoom Pharma- Saudi Arabia), and (DuspalinaAsia- Syria) using Ayah 6.S.X1.-T.-2D.- Solar cell CFI Analysis which was compared with Quoted value [21]
Summary
New Method for Estimation Mebeverine Hydrochloride Drugs Preparation by a New Analyser: Ayah 6S.X1(WSLEDs)-T.- Two Solar Cells Complied with C.F.I.A.
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