Abstract
Four new meroterpenoids (2–5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1–7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.
Highlights
Marine-derived fungi have recently become a hotspot of new and bioactive metabolites in the marine environment [1]
The NMR and optical rotation data were in agreement with those previously published, guignardone A [18]; the absolute configuration was confirmed by X-ray crystallography (Figure 2)
The structural differences of compounds 1–7 mainly occur in the isoprenoid chain, this may be the reason for their lack of activities
Summary
Marine-derived fungi have recently become a hotspot of new and bioactive metabolites in the marine environment [1]. Spiroquinazolines [3], cerebrosides [4], isobenzofurans [5,6], cytochalasins [2,7,8,9], and butyrolactones [10] have been isolated from the culture of A. flavipes. They showed antibiotic [9,11,12], cytotoxic [7], substance-p inhibitory [3], peptide deformylase inhibitory [5,6], and HIV-1 integrase inhibitory activities [8]
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