Abstract
New mechanisms involving the EGFR and FGF15/19 systems in liver regeneration and carcinogenesis
Highlights
In response to tissue injury the liver mounts a robust protective and regenerative response aimed at the restoration of the lost or damaged parenchyma
Normal hepatocytes express high levels of epidermal growth factor receptor (EGFR), EGFR activation contributes significantly to hepatocellular survival and proliferation during injury and regeneration, and plays a fundamental role in the negative regulation of liver acute phase response triggered by inflammatory cytokines [4]
Persistent AR up-regulation has been detected in chronic liver injury, and this growth factor plays an important role in hepatic fibrogenesis, a consequence of the dysregulated wound healing response occuring during chronic liver damage [5]
Summary
In response to tissue injury the liver mounts a robust protective and regenerative response aimed at the restoration of the lost or damaged parenchyma. One of the FXR target genes in the ileal enterocytes is fibroblast growth factor 19 (FGF19, FGF15 in rodents). We have identified a new role for FGF15/19 in liver regeneration after PH.
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