Abstract
Six new compounds, omaezol, intricatriol, hachijojimallenes A and B, debromoaplysinal, and 11,12-dihydro-3-hydroxyretinol have been isolated from four collections of Laurencia sp. These structures were determined by MS and NMR analyses. Their antifouling activities were evaluated together with eight previously known compounds isolated from the same samples. In particular, omaezol and hachijojimallene A showed potent activities (EC50 = 0.15–0.23 µg/mL) against larvae of the barnacle Amphibalanus amphitrite.
Highlights
Biofouling is a major cause of increased fuel consumption of ships and facilitates the spread of invasive marine organisms [1]
Laurencia sp., which was collected in Omaezaki, Japan, was extracted with MeOH
Most of the compounds obtained in this study were tested for antifouling activity against larvae of the barnacle Amphibalanus amphitrite (Table 4)
Summary
Biofouling is a major cause of increased fuel consumption of ships and facilitates the spread of invasive marine organisms [1]. Effective and new fouling treatment is needed to control and curb the introduction of non-indigenous species (NIS), that are introduced into local waters partly via ballast water uptake and discharge in vessels. Search for natural antifouling compounds to solve biofouling has been “a work in progress” for almost four decades. Industrial of natural productsutilization as antifouling agentsproducts would warrant systematic synthetic importanceutilization [6]. Industrial of natural as antifouling agents would efforts, and these have been implemented [5]. As a continuous effort, antifouling compounds such as elatol [13], omaezallene [14], and 2,10-dibromo-3-chloro-7-chamigrene our been searching novel and potent antifouling compounds from. As ahas continuous effort,forour group has been searching for novel and potent sp. Antifouling barnacle larvae and epiphytic diatom assays. 1) and activities new antifouling compounds from Laurencia sp
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