New Lycopodium alkaloids with neuroprotective activities from Lycopodium japonicum Thunb

Abstract

One new lycopodine-type alkaloid (1), one new natural product (2), and eight known analogs (3–10) were isolated from the whole plants of Lycopodium japonicum Thunb. The structures of 1–10 were determined based on extensive comprehensive spectroscopic analyses, including UV, IR, NMR, and HRESIMS. Moreover, the isolated alkaloids were evaluated for their neuroprotective activity against Hemin-induced HT22 cell damage. Notably, compounds 1 and 10 exhibited potential neuroprotective activities, with 21.45% and 20.55% increase in cell survival at 20 μM, respectively. Moreover, compounds 1 and 10 revealed protective effects on Hemin-induced apoptosis in HT22 cells.