Abstract
This work presents the synthesis, spectroscopic properties and single-crystal X-ray examination of the structure of 3-hydroxyiminoflavanone and its palladium complex. It presents the results of NMR (Nuclear Magnetic Resonance) spectroscopy, electron-density studies based on X-ray wavefunction refinement and theoretical calculations combined with QTAIM (Quantum Theory of Atoms in Molecules) and ELI-D (Electron Localizability Indicator) analyses. These offer an interesting new insight into the structures and behavior of flavanone and its complex, in solid state and in solution. The study also examines the cytotoxicity of the ligand and its complex against three human ovarian and lung cancer cell lines.
Highlights
Over the past 40 years, platinum-based drugs have been widely used in the treatment of many types of tumors including ovarian, testicular, non-small cell lung, head and neck and bladder cancers.Cisplatin (cis-[PtCl2 (NH3 )2 ], cis-diamminedichloridoplatinum) was found to be a effective anticancer drug when administrated as single agent or in combination with other compounds.its application is limited by serious side effects such as nephrotoxicity, myelotoxicity, ototoxicity, allergy, and the development of resistance in tumor cells [1,2,3]
The work presents a detailed description of the structure of 3-hydroxyiminoflavanone and its palladium(II) complex, and sheds new light on their structures in solution and in solid state
It shows that 3E(anti)-hydroxyiminoflavanone (1) reacts with tertrachloridopalladate(II) and forms complex
Summary
Over the past 40 years, platinum-based drugs have been widely used in the treatment of many types of tumors including ovarian, testicular, non-small cell lung, head and neck and bladder cancers.Cisplatin (cis-[PtCl2 (NH3 )2 ], cis-diamminedichloridoplatinum) was found to be a effective anticancer drug when administrated as single agent or in combination with other compounds.its application is limited by serious side effects such as nephrotoxicity, myelotoxicity, ototoxicity, allergy, and the development of resistance in tumor cells [1,2,3]. Over the past 40 years, platinum-based drugs have been widely used in the treatment of many types of tumors including ovarian, testicular, non-small cell lung, head and neck and bladder cancers. Cisplatin (cis-[PtCl2 (NH3 )2 ], cis-diamminedichloridoplatinum) was found to be a effective anticancer drug when administrated as single agent or in combination with other compounds. Its application is limited by serious side effects such as nephrotoxicity, myelotoxicity, ototoxicity, allergy, and the development of resistance in tumor cells [1,2,3]. Palladium complexes have been studied extensively, based on their structural analogy with platinum complexes. A variety of Pd(II) complexes have shown promising activity as antitumor, antiviral, antimalarial, antifungal and antimicrobial agents [4,5,6]. Most studies were not very encouraging because the
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