New Lipid Emulsions for the PN of Preterm Infant: Impact on Ara, Epa and Dha Status

Abstract

Background and aims: New lipid emulsions containing fish oil (FO) have recently became available and they could be proven to be a good source of Arachidonic Acid (ARA) and Docosahexaenoic Acid (DHA). We compared in preterms the impact of 2 FO containing lipid emulsions and 3 conventional preparations on plasma phospholipid fatty acids (PLFA) status. Methods: Seventyfive preterms < 1250g were randomized (15 in each groups) to receive PN with MS (50%MCT,50%soy),OS (80%olive,20%soy), SO (100%soy),FMS (10%FO,50%MCT,40%soy) and FOMS (15%FO,25%olive,30%MCT,30%soy). The IV lipid intake was increased in a stepwise fashion to 2,5 g•kg-1•d-1 by PN d7. All infants were on minimal enteral feeding. Plasma PLFA were determined at d7. Results: ARA and DHA intakes (mg•kg-1•d-1) on PN d7 are in table 2. ARA, EPA and DHA of plasma PL (Mol%) on PN d7 are in table 2. Table 1* Conclusion: Both the 10% and 15% FO containing emulsions ensured intrauterine DHA intakes. Plasma ARA PL was lower,Eicosapentaenoic Acid (EPA) and DHA higher in FO groups compared with the standards. The potential benefits on neurodevelopment and on inflammation need large randomized clinical trials.