Abstract
Three previously undescribed iridoids, cornusfurals A–C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.
Highlights
Cornus officinalis (Cornus) is a shrub distributed in Eastern Asia
In our previous pharmacology studies, we found that the macroporous resin 40% ethanol elution fraction of the ethanol extract of C. officinalis exhibited potent neuroprotective activity, and four new iridoid glycosides were isolated [17]
Ethanol elution fraction was further isolated by combination of silica column chromatography, low-pressure liquid chromatography, Sephadex the combination of gel silica gel column chromatography, low-pressure liquid chromatography, LH-20 chromatography, and HPLC,and generating three new compounds (Figure 1). (Figure 1)
Summary
Cornus officinalis (Cornus) is a shrub distributed in Eastern Asia. The fruits of C. officinalis, named “shanzhuyu”, have traditionally been used for nourishing the liver and kidneys for thousands of years [1]. Phytochemical investigation of the fruits of C. officinalis has demonstrated the presence of iridoid glycosides, flavonoids, terpenoids, and polyphenols [7,8,9,10,11]. Iridoids were found to be the most important constituents and are considered to be active components of the extracts. The main iridoid glycoside from C. officinalis, has been reported to have antidepressive activity in recent studies [15,16]. In our previous pharmacology studies, we found that the macroporous resin 40% ethanol elution fraction of the ethanol extract of C. officinalis exhibited potent neuroprotective activity, and four new iridoid glycosides were isolated [17]. According to the HPLC spectroscopic characteristics, there are still many similar constituents which were suspected to have potential activities in this fraction
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