Abstract
The fluorination of dendritic structures has attracted special attention in terms of self-assembly processes and biological applications. The presence of fluorine increases the hydrophobicity of the molecule, resulting in a better interaction with biological membranes and viability. In addition, the development of 19F magnetic resonance imaging (19F-MRI) has greatly increased interest in the design of new fluorinated structures with specific properties. Here, we present the synthesis of new water-soluble fluorinated carbosilane dendrons containing fluorinated chains in different positions on the skeleton, focal point or surface, and their preliminary supramolecular aggregation studies. These new dendritic systems could be considered as potential systems to be employed in drug delivery or gene therapy and monitored by 19F-MRI.
Highlights
Since their discovery, the well-defined architecture of dendrimers has promoted their use thanks to their highly multifunctional skeleton, which allows for the concentration of a high number of units of interest in the same structure and permits fragments of a different nature to be introduced, combining both properties
Fluorinated reagents employed in the fluorine-containing dendrons synthesis
−7 M, the synthetic route opens the door to extrapolate this procedure to dendritic
Summary
The well-defined architecture of dendrimers has promoted their use thanks to their highly multifunctional skeleton, which allows for the concentration of a high number of units of interest in the same structure and permits fragments of a different nature to be introduced, combining both properties. The introduction of different types of fragment enables change in the physicochemical properties of the dendritic structure, yielding molecules with relevance in diverse fields such as catalysis [1], material science [2] or biomedicine [3]. Taking advantage of these structural features of dendrimers, fluorination has attracted the attention of researchers to explore catalytic [4] or electronic properties [5], special interest has been shown in supramolecular chemistry [6] or biology [7] in recent years. The presence of fluorine stimulates the interaction between biomembranes, imparting a favorable impact on biocompatibility
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
