Abstract
In France during 2012, human enterovirus 71 (EV-A71) subgenogroup C4 strains were detected in 4 children hospitalized for neonatal fever or meningitis. Phylogenetic analysis showed novel and independent EV-A71 introductions, presumably from China, and suggested circulation of C4 strains throughout France. This observation emphasizes the need for monitoring EV-A71 infections in Europe.
Highlights
The Study In France, EV infections diagnosed in hospital settings have been voluntarily reported to the National Institute for Public Health by a network of hospital laboratories since 2000 [9]
Most of the genotyped strains were detected in cerebrospinal fluid (CSF) samples from patients with neonatal fever, meningitis, or meningoencephalitis or in samples from patients with hand-foot and mouth disease (HFMD) or herpangina
For the child with meningitis, reverse transcription PCR was negative for EV-A71 in the CSF specimen, but an EV-A71 strain was isolated from a throat swab specimen
Summary
The Study In France, EV infections diagnosed in hospital settings have been voluntarily reported to the National Institute for Public Health by a network of hospital laboratories since 2000 [9]. In 2010, a total of 158 community cases of HFMD and herpangina were reported through a sentinel surveillance system implemented in Clermont-Ferrand, France [12]. Most of the genotyped strains were detected in cerebrospinal fluid (CSF) samples from patients with neonatal fever, meningitis, or meningoencephalitis or in samples from patients with HFMD or herpangina. The EVA71 C4 infections were detected throughout the year in 3 regions (Brittany, Ile de France, and Provence-Alpes-Côte d’Azur).
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