Abstract
Data accumulated over the past four decades have confirmed that adult hippocampal neurogenesis (HN) plays a key role in the wide spectrum of hippocampal pathology. Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although neurogenesis in persistent germinative zones is altered in the adult rodent models of epilepsy, the effects of seizure-induced neurogenesis in the epileptic brain, in terms of either a pathological or reparative role, are only beginning to be explored. In this review, we described the most recent advances in neurogenesis in epilepsy and outlooked future directions for neural stem cells (NSCs) and epilepsy-in-a-dish models. We proposed that it may help in refining the underlying molecular mechanisms of epilepsy and improving the therapies and precision medicine for patients with epilepsy.
Highlights
Despite being assumed to be non-existent for decades, the occurrence and regulation of hippocampal neurogenesis (HN) in adult mammals has been widely accepted [1]
It is clear that these positive results further increase the interest in HN following theconfirmation that they existed in the adult human brain, which was paralleled by a drastic debate over the sequencing methods, disease model construction, and a possible reinterpretation of the functional role in the human brain [3]
Adult neurogenesis in the mammalian brain is a process by which functional neurons are generated from the division of neural stem cells (NSCs), which have a high capacity for long-term self-renewal while giving rise to the neurons and glia in the subventricular zone/olfactory bulb (SVZ/OB) system and hippocampal dentate gyrus (DG) from the embryo throughout the lifespan of animals [4]
Summary
Edited by: Ayanabha Chakraborti, University of Alabama at Birmingham, United States. Reviewed by: Sreekanth Puttachary, Oregon State University, United States Victor Rodrigues Santos, Federal University of Minas. Data accumulated over the past four decades have confirmed that adult hippocampal neurogenesis (HN) plays a key role in the wide spectrum of hippocampal pathology. Neurogenesis in persistent germinative zones is altered in the adult rodent models of epilepsy, the effects of seizure-induced neurogenesis in the epileptic brain, in terms of either a pathological or reparative role, are only beginning to be explored. We described the most recent advances in neurogenesis in epilepsy and outlooked future directions for neural stem cells (NSCs) and epilepsy-in-a-dish models. We proposed that it may help in refining the underlying molecular mechanisms of epilepsy and improving the therapies and precision medicine for patients with epilepsy
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